Increased islet apoptosis in Pdx1+/– mice
J. Clin. Invest. James D. Johnson, et al. 111:1147 doi:10.1172/JCI16537 [
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Figure 7β cell and α cell architecture in
Pdx1+/– islets. Insulin (
a,
c,
e, and
g) and glucagon (
b,
d,
f, and
h) are stained red in adjacent 5-μm-thick sections.
Pdx1+/– islets from 3-month-old mice show striking disruption of islet architecture compared with littermate controls. Note the presence of cells stained for insulin and glucagon in
e and
f (arrowheads). Localization of α cells to the periphery was reduced in 1-year-old mice from both groups.
