Increased islet apoptosis in Pdx1+/– mice
J. Clin. Invest. James D. Johnson, et al. 111:1147 doi:10.1172/JCI16537 [
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Figure 1Glucose tolerance and secretagogue-induced pancreatic insulin release in
Pdx1+/– mice. (
a) IPGTTs are shown for males (
n = 9
Pdx1+/+;
n = 8
Pdx1+/–) and females (
n = 3
Pdx1+/+;
n = 3
Pdx1+/–). (
b) Insulin release from perfused pancreata of male
Pdx1+/+ (
n = 5) and
Pdx1+/– (
n = 5) mice in response to stepwise increases to 20 mM glucose (black bar) and 20 mM KCl (white bar). (
c) Insulin release from perfused pancreata of
Pdx1+/+ (
n = 3) and
Pdx1+/– (
n = 3) mice in response to a linear elevation from 2 mM to 26 mM glucose. Insulin secretion in response to 20 mM arginine (arg) was assayed in the continued presence of 26 mM glucose (G) (note the different scale). Data are from mice 8–10 weeks of age.
