Prolactin modulates the naive B cell repertoire
J. Clin. Invest. Elena Peeva, et al. 111:275 doi:10.1172/JCI16530 [
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Figure 6Prolactin effects on B cells are genetically determined. Ten murine prolactin–treated and 10 placebo-treated R4A-γ2b C57Bl/6 mice were evaluated for serum anti-DNA reactivity, glomerular IgG deposits, and anti-DNA–secreting B cells. (
a) There was no difference in the serum anti-DNA reactivity between prolactin- and placebo-treated mice. (
b) Transgene-expressing B cells were equal in both prolactin- and placebo-treated mice. The total number of splenic B cells expressing γ2b was 2.12 ± 0.63 × 10
6 in placebo-treated mice, as compared with 2.23 ± 0.55 × 10
6 in prolactin-treated mice.(
c) Prolactin-treated mice did not exhibit a higher number of B cells spontaneously secreting anti-DNA antibody or an increased responsiveness to anti-CD40 antibody and IL-4. Cells, anti-DNA antibody-secreting cells.
