Adipose-derived resistin and gut-derived resistin-like molecule–β selectively impair insulin action on glucose production
J. Clin. Invest. Michael W. Rajala, et al. 111:225 doi:10.1172/JCI16521 [Go to this article.]

Figure 3
Effect of resistin and RELMβ on glucose disposal and production during insulin clamp studies. The measurements were obtained while plasma glucose concentration was maintained at approximately 7 mM under steady-state conditions. (a) Effect of resistin and RELMβ on the rate of glucose infusion (GIR; mg/kg/min). (b) Effect of resistin and RELMβ on the rate of glucose disappearance (Rd; mg/kg/min). (c) Effect of resistin and RELMβ on the rate of glucose production (GP; mg/kg/min). (d) Effect of resistin and RELMβ on hepatic insulin sensitivity (HIS; μU/ml). To take into account differences between animals in circulating plasma insulin levels during the insulin clamp studies, the same index of hepatic insulin sensitivity described in the Figure 2c legend was used. *P < 0.05 vs. vehicle.