Effect of resistin and RELMβ during pancreatic clamp studies. The measurements were obtained while plasma glucose concentration was maintained at approximately 8.5 mM under steady-state conditions. (a) Rates of insulin infusion (IIR; mU/kg/min) required to maintain the plasma glucose concentrations at basal levels. (b) Effect of resistin and RELMβ on the rate of glucose production (GP; mg/kg/min). (c) Effect of resistin and RELMβ on hepatic insulin sensitivity (HIS). To take into account the differences in circulating plasma insulin levels during the pancreatic clamp studies, an index of HIS was calculated as GP^–1/insulin (μU/ml) × 100. (d) Effect of resistin and RELMβ on peripheral insulin sensitivity (PIS). To take into account the differences in circulating plasma insulin levels during the pancreatic clamp studies, an index of peripheral insulin sensitivity was calculated as Rd (mg/kg/min)/insulin (μU/ml). Rd, rate of glucose disappearance. *P < 0.05 vs. vehicle.