Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
J. Clin. Invest. Graciela Andonegui, et al. 111:1011 doi:10.1172/JCI16510 [
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Figure 9Effect of systemic LPS on circulating leukocytes and leukocyte kinetics in cremaster postcapillary venules in
TLR4+/+,
TLR4–/–, and TLR4 chimeric mice. (
a and
b) Circulating leukocytes (
a) and leukocyte rolling flux (
b) in cremaster tissue of untreated (white bars) and LPS-treated (black bars)
TLR4+/+,
TLR4–/–,
LeukocyteTLR4–/–, and
EndotheliumTLR4–/– (
Endothel.TLR4–/–) chimeric mice. Data are presented as the arithmetic mean ± SEM of six to eight mice per group and represent experiments using both sets of chimeras. *
P < 0.05 vs. untreated mice;
#P < 0.05 vs. LPS-treated
LeukocyteTLR4–/– mice.
