Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
J. Clin. Invest. Graciela Andonegui, et al. 111:1011 doi:10.1172/JCI16510 [Go to this article.]

Figure 8
Expression of TLR4 on bone marrow–derived and non-bone-marrow–derived lung macrophages. Macrophages were isolated from EndotheliumTLR4^–/– (Endothel.TLR4^–/–) and LeukocyteTLR4^–/– chimeric mouse lungs, and then treated with LPS for 18 hours or left untreated. Complementary DNA was synthesized, and RT-PCR of iNOS and GAPDH expression was performed. Results shown are representative of three experiments per mouse group using chimeras generated with C57BL/6 and TLR4^–/– mice.