Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
J. Clin. Invest. Graciela Andonegui, et al. 111:1011 doi:10.1172/JCI16510 [
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Figure 7Effect of LPS on P-selectin expression in TLR4 chimeric mice. Expression of P-selectin in lung tissue of untreated
TLR4+/+ mice (white bar) and LPS-treated
LeukocyteTLR4–/– and
EndotheliumTLR4–/– (
Endothel.TLR4–/–) chimeric mice (black bars). Data are presented as the arithmetic mean ± SEM of four mice per group and represent experiments using chimeric mice generated with C57BL/6 vs.
TLR4–/– mice. *
P < 0.05 vs. untreated
TLR4+/+ mice;
#P < 0.05 vs.
LeukocyteTLR4–/– mice. ID, injected dose.
