Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
J. Clin. Invest. Graciela Andonegui, et al. 111:1011 doi:10.1172/JCI16510 [
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Figure 5LPS-induced neutrophil sequestration into the lungs of
LeukocyteTLR4–/– mice. Mice were untreated (white bars) or treated with LPS for 4 hours (black bars), and then lungs were harvested and MPO levels determined in
TLR4+/+,
TLR4–/–,
LeukocyteTLR4–/–, and
EndotheliumTLR4–/– (
Endothel.TLR4–/–) chimeric mice. Data are expressed as the arithmetic mean ± SEM of five mice per group and represent experiments pooled from both sets of chimeric mice. *
P < 0.05 vs. untreated mice.
