Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
J. Clin. Invest. Graciela Andonegui, et al. 111:1011 doi:10.1172/JCI16510 [Go to this article.]

Figure 4
LPS stimulates neutrophil sequestration into the lungs in E/P-selectin^–/– and CD18^–/– mice. Mice were treated without LPS (white bars) or with LPS (black bars) for 4 hours, and then whole blood was taken by cardiac puncture and lungs harvested. (a) Circulating-leukocyte counts in harvested lungs. (b) MPO levels in harvested lungs. Data are expressed as the arithmetic mean ± SEM of four mice per group. *P < 0.05 vs. untreated mice.