Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
J. Clin. Invest. Graciela Andonegui, et al. 111:1011 doi:10.1172/JCI16510 [Go to this article.]

Figure 1
Systemic LPS induces neutrophil sequestration into the lungs and reduces the number of circulating leukocytes in TLR4^+/+ mice. Mice were untreated or treated with LPS for 30 minutes, 4 hours, or 12 hours. At these times the lungs were harvested to determine MPO levels (a), and samples of blood were drawn by cardiac puncture to assess the number of circulating leukocytes (b). Data are expressed as the arithmetic mean ± SEM of four to five mice per group. *P < 0.05 vs. untreated mice (0 hours).