The suppressor of cytokine signaling–1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury
J. Clin. Invest. Hideo Yasukawa, et al. 111:469 doi:10.1172/JCI16491 [Go to this article.]

Figure 3
Deterioration of cardiac function after CVB3 inoculation in SOCS1 transgenic mice. Echocardiography was performed 3 days after virus inoculation (n = 3 mice per group). Upper panels show that the LVEDD and LVESD were significantly elevated in transgenic mice (black bars) as compared with wild-type (white bars). The %FS, a parameter of cardiac function, was significantly decreased in transgenic mice as compared with wild-type mice. The lower panel shows the typical M-mode image of the two groups. Results are shown as means ± SE. *P < 0.01 for the comparison of SOCS1 transgenic mice with wild-type littermates. Tg, transgenic.