Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production
J. Clin. Invest. Simon J. Fisher, et al. 111:463 doi:10.1172/JCI16426 [Go to this article.]

Figure 3
HGP (a) and glucose turnover rates (b) in the basal period and in response to insulin infusion (20 mU/kg/min) during the hyperinsulinemic clamp as assessed using [3-³H]-glucose tracer dilution methodology. Surprisingly, in spite of varied insulin levels, there was no difference in basal HGP. During the hyperinsulinemic-euglycemic clamp, insulin suppressed HGP by 82% ± 17% in control mice but failed to suppress HGP in both LIRKO and LIRKO+STZ mice. Data are shown for Lox-Lox controls, n = 6 (white bars); LIRKO mice, n = 7 (black bars); and LIRKO+STZ mice, n = 6 (gray bars). Statistical differences between study groups are discussed in Results.