Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production
J. Clin. Invest. Simon J. Fisher, et al. 111:463 doi:10.1172/JCI16426 [
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Figure 2Insulin (
a), FFA (
b), and glucagon (
c) levels in the basal period and in response to insulin infusion (20 mU/kg/min) during the hyperinsulinemic clamp. Data are shown for Lox-Lox controls,
n = 6 (white bars); LIRKO mice,
n = 7 (black bars); and LIRKO+STZ mice,
n = 6 (gray bars). Statistical differences between study groups are discussed in Results.
