Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production
J. Clin. Invest. Simon J. Fisher, et al. 111:463 doi:10.1172/JCI16426 [Go to this article.]

Figure 1
Blood glucose levels (a) and glucose infusion rates (b) during the euglycemic-hyperinsulinemic clamp. After basal sampling at time 0, insulin was infused (20 mU/kg/min) for the duration of the 2-hour clamps. Blood glucose (from tail-vein samples) was clamped at eu-glycemic levels (∼125 mg/dl) with intravenous infusion of dextrose (50%). Treatment groups were Lox-Lox control, n = 6 (circles); LIRKO, n = 7 (triangles); and LIRKO+STZ, n = 6 (squares).