JCI - Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Jacqueline D. Trudeau, Carolyn Kelly-Smith, C. Bruce Verchere, John F. Elliott, Jan P. Dutz, Diane T. Finegood, Pere Santamaria, Rusung Tan

Published in Volume 111, Issue 2

J Clin Invest. 2003; 111(2):217–223 doi:10.1172/JCI16409

Abstract | Full text | PDF

Options: View larger image (or click on image)

Figure 2

NRP-V7–reactive T cells detected in peripheral blood indicate their presence in pancreatic islets. The mean (± SEM) percentage of NRP-V7 tetramer-positive CD8⁺ B220^– cells within peripheral blood, pancreatic islets, spleen, and pancreatic draining lymph nodes are shown for individual NOD mice of 9–10 (gray bars; n = 7), 11–14 (black bars; n = 13), and 15–17 (white bars; n = 10) weeks of age. The inset shows a representative staining of each tissue from a single 12-week-old mouse. Numbers indicate the percentage of CD8⁺ B220^– tetramer-positive cells.