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Jacqueline D. Trudeau, Carolyn Kelly-Smith, C. Bruce Verchere, John F. Elliott, Jan P. Dutz, Diane T. Finegood, Pere Santamaria, Rusung Tan
J Clin Invest. 2003;
111(2):217
doi:10.1172/JCI16409
Abstract |
Full text
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utoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic β cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands.
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Citations to this article
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(26)
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Proceedings of the National Academy of Sciences
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2011 |
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Proceedings of the National Academy of Sciences
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2010 |
The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach.
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International Immunology
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Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands.
Liliana G Petrich de Marquesini, Antonis K Moustakas, Ian J Thomas, Li Wen, George K Papadopoulos, F Susan Wong
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Eur. J. Immunol.
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2008 |
Priming and effector dependence on insulin B:9–23 peptide in NOD islet autoimmunity
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J. Clin. Invest.
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2007 |
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Jun Yamanouchi, Dan Rainbow, Pau Serra, Sarah Howlett, Kara Hunter, Valerie E S Garner, Andrea Gonzalez-Munoz, Jan Clark, Riitta Veijola, Rose Cubbon, Show-Ling Chen, Raymond Rosa, Anne Marie Cumiskey, David V Serreze, Simon Gregory, Jane Rogers, Paul A Lyons, Barry Healy, Luc J Smink, John A Todd, Laurence B Peterson, Linda S Wicker, Pere Santamaria
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Nat Genet
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Expert Rev Endocrinol Metab
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Edwin Liu, Marcella Li, Jean Jasinski, Masakazu Kobayashi, Roberto Gianani, Maki Nakayama, George S. Eisenbarth
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Cell Biochem Biophys
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2007 |
Modeling Cyclic Waves of Circulating T Cells in Autoimmune Diabetes
Joseph M. Mahaffy, Leah Edelstein-Keshet
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SIAM J. Appl. Math.
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Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse
J. D. Trudeau, T. Chandler, G. Soukhatcheva, C. B. Verchere, R. Tan
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Diabetologia
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2007 |
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