Pacemaker channel dysfunction in a patient with sinus node disease
J. Clin. Invest. Eric Schulze-Bahr, et al. 111:1537 doi:10.1172/JCI16387 [Go to this article.]

Figure 5
Functional characterization of homomeric wild-type and HCN4–573X channels in COS-7 cells in the presence of 8-Br-cAMP. Shown are representative current traces of wild-type (a) or HCN4-573X (c) channels elicited by 5-second-long hyperpolarizing voltage steps from –40 mV to –120 mV in the presence of 8-Br-cAMP. Voltage dependence of wild-type (b) and HCN4-573X (d) conductances in the absence (black circles) or presence (white circles) of 1 mM 8-Br-cAMP. Absence of error bars indicates errors smaller than the symbol size.