Pacemaker channel dysfunction in a patient with sinus node disease
J. Clin. Invest. Eric Schulze-Bahr, et al. 111:1537 doi:10.1172/JCI16387 [Go to this article.]

Figure 4
Functional characterization of homomeric HCN4 and HCN4-573X channels in COS-7 cells under control conditions. Representative current traces of wild-type (a) or HCN4-573X (c) channels elicited by 5-second-long hyperpolarizing voltage steps from –40 mV to –120 mV under control conditions. Relative open probability of wild-type (b) and HCN4-573X (d) channels was dependent on test-pulse duration (gray circles, 2 seconds; black circles, 5 seconds; white circles, 15 seconds). Absence of error bars indicates errors smaller than the symbol size.