Sensitizing antigen-specific CD8⁺ T cells for accelerated suicide causes immune incompetence
J. Clin. Invest. Christoph Wasem, et al. 111:1191 doi:10.1172/JCI16344 [Go to this article.]

Figure 4
Impaired antiviral cytotoxicity in Bis VIII–treated mice. Animals were infected with LCMV and treated with PBS (open and filled squares) or Bis VIII (open and filled circles) as described in Methods. On day 7 after infection, spleen cells were isolated and cocultured at various effector/target (E:T) ratios with LCMV peptide–labeled (gp33, filled squares and circles) or control peptide–labeled (adn, open squares and circles) target cells. Virus-specific cytotoxicity was assessed by target cell lysis (⁵¹Cr release). Mean values ± SD from a typical experiment of three performed are shown.