Endothelial lipase is a major determinant of HDL level
J. Clin. Invest. Tatsuro Ishida, et al. 111:347 doi:10.1172/JCI16306 [
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Figure 5Phospholipase activity in genetic models. Phospholipase activity in different genetic lines was compared between pre- and postheparin injection samples. A significantly greater level of postheparin phospholipase activity was observed in the transgenic lines (*
P < 0.05), and a significantly lower level of postheparin augmentation of phospholipase activity was found in the knockout animals (*
P < 0.05) as compared to the wild-type controls. The preheparin levels of plasma phospholipase activity were as follows (mean ± SEM): wild-type animals, 519 ± 22.3 nmol FFA/ml/hr; knockout animals, 521 ± 5.4 nmol FFA/ml/hr; and transgenic animals, 510.5 ± 20.2 nmol FFA/ml/hr. PLase, phospholipase activity; Tg, h
LIPGTg; KO,
LIPG–/–.
