The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
J. Clin. Invest. Shaosong Zhang, et al. 111:833 doi:10.1172/JCI16290 [
Go to this article.]
Figure 4Inhibition of
β-MHC and
ANF gene expression in
Grb2+/– cardiac tissue after pressure overload. Ventricular tissue was obtained 7 days after TAC or sham operation from
Grb2+/+ and
Grb2+/– mice, and RNA was purified from the tissue samples. Gene expression was analyzed by use of quantitative real-time RT-PCR with specific primers and probes. GAPDH was used as an internal control in all cases. (
a)
β-MHC gene expression in
Grb2+/+ and
Grb2+/– ventricular tissue. (
b)
ANF gene expression in
Grb2+/+ and
Grb2+/– ventricular tissue. AU, arbitrary units.
