The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
J. Clin. Invest. Shaosong Zhang, et al. 111:833 doi:10.1172/JCI16290 [Go to this article.]

Figure 3
Histological analysis of Grb2^+/+ and Grb2^+/– LV tissue 7 days after TAC or sham operation. Ventricular tissue sections from (a) Grb2^+/+ mouse, stained with H&E after sham operation; (b) Grb2^+/+ mouse, stained with H&E after TAC; (c) Grb2^+/– mouse, stained with H&E after sham operation; (d) Grb2^+/– mouse, stained with H&E after TAC; (e) Grb2^+/+ mouse, stained with Masson trichrome after sham operation; (f) Grb2^+/+ mouse, stained with trichrome after TAC. Note the increased extracellular matrix content (blue color), cardiomyocyte enlargement, and disarray. (g) Ventricular tissue section from Grb2^+/– mouse, stained with trichrome after sham operation. (h) Ventricular tissue section from Grb2^+/– mouse, stained with trichrome after TAC. The original magnification was ×400 in all sections.