The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
J. Clin. Invest. Shaosong Zhang, et al. 111:833 doi:10.1172/JCI16290 [Go to this article.]

Figure 2
Reduced hypertrophic response to pressure overload in Grb2^+/– mice. (a) Gross morphology of hearts from Grb2^+/+ (left) and Grb2^+/– (right) mice 7 days after TAC. (b) Morphometric analysis of cardiac hypertrophy in Grb2^+/+ and Grb2^+/– mice. Seven days after TAC or sham operation, cardiac chambers were dissected and weighed to determine LVW/BW (*P < 0.01 vs. sham-operated control).