Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor
J. Clin. Invest. Gillian S. Ashcroft, et al. 111:1309 doi:10.1172/JCI16288 [
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Figure 1MIF localizes to keratinocytes, endothelium, and inflammatory cells during wound healing. (
a–
c) Day 3 wounds from BALB/C mice illustrate suprabasal keratinocyte staining for MIF (
b, arrow), endothelial cells (
c, arrow), and perivascular inflammatory cell staining (
c, green arrows). (
a) represents IgG isotype control negative staining (arrow indicates epidermis). All scale bars represent 10 μm. (
d) Temporal decrease in wound section immunostaining scores for MIF as compared with normal skin (normal skin scored as 0). Results represent medians (black lines across boxes), boxes represent interquartile ranges, and the bars extending from the boxes indicate the highest and lowest values (
n = 6 for each group, *
P < 0.05 versus day 3).
