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Abstract

Adipose tissue lipolysis supplies circulating FFAs, which largely meet lipid fuel needs; however, excess FFAs, can contribute to the adverse health consequences of obesity. Because “normal” FFA release has not been well defined, average (mean of 4 days) basal FFA release and its potential regulation factors were measured in 50 lean and obese adults (25 women). Resting energy expenditure (REE), but not body composition, predicted most of the interindividual variation in FFA release. There was a significant, positive linear relationship between palmitate release and REE; however, women released approximately 40% more FFA than men relative to REE. Neither plasma palmitate concentrations nor respiratory quotient by indirect calorimetry differed between men and women. Glucose release rates were not different in men and women whether related to REE or fat free mass. These findings indicate that nonoxidative FFA clearance is greater in women than in men. This could be an advantage at times of increased fuel needs. We conclude that “normal” adipose tissue lipolysis is different in men and women and that the fuel export role of adipose tissue in obesity will need to be reassessed.

Authors

Søren Nielsen, ZengKui Guo, Jeanine B. Albu, Samuel Klein, Peter C. O’Brien, Michael D. Jensen

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Total citations by year in Crossref

Year: 2014 2013 2010 2009 2007 2005 2004 Total
Citations: 1 1 1 1 1 1 1 7
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Citations to this article in Crossref (7)

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European Journal of Clinical Nutrition 2014
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UA White, YD Tchoukalova
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013
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Journal of biomedicine & biotechnology 2010
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Clinical Lipidology 2009
Regional fat deposition as a factor in FFA metabolism
SB Votruba, MD Jensen
Annual Review of Nutrition 2007
Pioglitazone increases non-esterified fatty acid clearance in upper body obesity
S Shadid, MD Jensen
Diabetologia 2005
Physiological regulation of NEFA availability: lipolysis pathway
V Stich, M Berlan
Proceedings of the Nutrition Society 2004

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