Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis
J. Clin. Invest. Julian J. Lum, et al. 111:1547 doi:10.1172/JCI16233 [Go to this article.]

Figure 9
Effects of wild-type or R77Q Vpr on T cell depletion in vivo. Balb-c mice (21–28 days old) were intravenously injected with vehicle control alone (data not shown) or vehicle containing wild-type Vpr or mutant Vpr. The absolute CD4⁺ or CD8⁺ T cell number at baseline, 24, and 48 hours after injection was determined by FACS analysis. Data are presented as the percent decrease from baseline normalized to control mice for CD4⁺ T cells (a) or CD8⁺ T cells (b).