Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis
J. Clin. Invest. Julian J. Lum, et al. 111:1547 doi:10.1172/JCI16233 [
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Figure 3Decreased activation of caspase-8 in cells treated with Vpr R77Q. Wild-type Vpr causes complete cleavage of caspase-8 into the intermediate and active p18 fragments in a manner similar to that seen after Fas ligation, using the agonistic anti-Fas antibody CH-11. Treatment with R77Q peptide has decreased caspase-8 cleavage and undetectable p18 fragments.
