Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
J. Clin. Invest. Paul J. Egan, et al. 111:915 doi:10.1172/JCI16156 [
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Figure 3Histopathology of joints from
SOCS-1+/+ IFN-γ–/– and
SOCS-1–/– IFN-γ–/– mice. Acute inflammatory arthritis was induced by intra-articular injection of 200 μg mBSA into the knee joint followed by three daily subcutaneous injections of 20 ng IL-1β. Mice were sacrificed on day 7, knee joints were fixed in 10% formalin, and H&E-stained frontal sections were prepared. Knee joints were taken from nonarthritic
SOCS-1–/– IFN-γ–/– mice (
a and
b), arthritic
SOCS-1+/+ IFN-γ–/– mice (
c and
d), and arthritic
SOCS-1–/– IFN-γ–/– mice (
e and
f). Magnification:
a,
c, and
e, ×40;
b,
d, and
f, ×100.
