Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
J. Clin. Invest. Paul J. Egan, et al. 111:915 doi:10.1172/JCI16156 [
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Figure 2Histological assessment of acute inflammatory arthritis in C57BL/6 and
IFN-γ–/– mice. Acute inflammatory arthritis was induced by intra-articular injection of 200 μg mBSA into the knee joint followed by three daily subcutaneous injections of 250 ng IL-1β. Mice were sacrificed on day 7 following mBSA injection. H&E-stained joint sections were graded for five features of inflammatory arthritis, each on a scale of 0 (normal) to 5 (severe). Results shown are the mean + SEM of 16 knee joints and are representative of three independent experiments.
