Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts
J. Clin. Invest. Victor Turcanu, et al. 111:1065 doi:10.1172/JCI16142 [Go to this article.]

Figure 3
Th2 skewing of peanut-specific responses from a PA donor contrasts with the Th1-biased response induced by nonallergenic food antigens. PBMCs isolated from a PA donor, labeled with CFSE, and cultured in the presence of antigens for 7 days were restimulated with PMA and ionomycin in the presence of brefeldin A for 6 h, then cytokine production was assessed using intracellular cytokine staining. Plots show IFN-γ/IL-4 production (percentage of cytokine positive cells) by the antigen-specific (CFSE^low) cells specific for PPD (a), TT (b), β-lactoglobulin (c), OVA (d), and peanuts (e).