Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
J. Clin. Invest. M. Llanos Casanova, et al. 111:43 doi:10.1172/JCI16116 [
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Figure 5Cannabinoids inhibit skin tumor growth in vivo. PDV.C57 cells were injected subcutaneously in mice. When tumors had reached the desired size, animals were treated with either vehicle (Co), WIN-55,212-2 (WIN), or JWH-133 (JWH), for 11 days. (
a) Tumor size (
n = 8 for each experimental group). *Significantly different (
P < 0.01) from control mice. (
b) Examples of subcutaneous tumors in the flank of mice after the indicated treatments. (
c) Appearance of tumors dissected from mice after the indicated treatments.