Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
J. Clin. Invest. Christopher T. Ritchlin, et al. 111:821 doi:10.1172/JCI16069 [Go to this article.]

Figure 7
RANKL and OPG expression in the PsA synovium. Retrieval tissues containing synovium from PsA patients were processed for immunohistochemistry with antibodies specific for RANKL and OPG as described in Methods. A representative synovial membrane from a PsA patient stained with anti-RANKL antibody (a), anti-OPG antibody (b), secondary antibody only (c), and H&E (d) are shown photographed at ×20. Of note is the very specific and intense RANKL staining by synovial lining cells and the OPG staining restricted to the endothelial cells below the synovial lining.