Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
J. Clin. Invest. Christopher T. Ritchlin, et al. 111:821 doi:10.1172/JCI16069 [Go to this article.]

Figure 6
RANK expression in the psoriatic joint. Tissues from PsA patients containing synovium and bone were obtained following surgery and processed for immunohistochemistry as described in Methods. Antibodies specific for RANK stain red-brown. RANK-positive osteoclasts (arrows) are prominently located at the synovial edge of the pannus-bone interface, shown photographed at ×20 (a), and RANK-positive mononuclear cells increase in number moving from the endothelium (asterisks) to the erosion front (×20) (b). In subchondral bone, RANK-positive osteoclasts were observed in cutting cones that are void of other cell types, as shown photographed at ×20 magnification (c). RANK-positive mononuclear cells and osteoclasts (arrows) surround an endothelial cell traversing subchondral bone (d).