Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
J. Clin. Invest. Christopher T. Ritchlin, et al. 111:821 doi:10.1172/JCI16069 [Go to this article.]

Figure 4
Cultured PsA PBMCs erode bone in a wafer assay. PBMCs were cultured with or without MCSF and RANKL on cortical bovine bone wafers. (a) After 21 days the wafers were stained with toluidine blue to identify resorption lacunae, shown photographed at ×10. Representative PsA and control samples are shown. (b) The percentages of eroded surface area on the wafers from unstimulated cultures from PsA patients (n = 6) and healthy controls (n = 6) were quantified as described in Methods.