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Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
Raymond J. Steptoe, Janine M. Ritchie, Leonard C. Harrison
Published in Volume 111, Issue 9
J Clin Invest. 2003; 111(9):1357–1363 doi:10.1172/JCI15995
This article Copyright © 2003, The American Society for Clinical Investigation
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Figure 5

T cell recall responses to OVA immunization. Mice were immunized subcutaneously with OVA 10 weeks after BMT, and recall responses of splenic T cells were measured 14 days later. T cell proliferation in the presence of OVA was similar in recipients of T cell–depleted NOD (inverted triangles) or NOD-PI (triangles) BM and in age-matched control NOD mice (squares). Data are from individual mice pooled from three separate experiments in which BMT from NOD and NOD-PI was performed in parallel.

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