H Abe, N Yamada, K Kamata, T Kuwaki, M Shimada, J Osuga, F Shionoiri, N Yahagi, T Kadowaki, H Tamemoto, S Ishibashi, Y Yazaki, M Makuuchi
J Clin Invest.
1998;
101(8):1784–1788
doi:10.1172/JCI1594
This article Copyright © 1998, The American Society for Clinical Investigation
Abstract
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nsulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance. Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice. Furthermore, lipoprotein lipase activity was lower than in normal mice, suggesting impaired lipolysis to be involved in the increase in plasma triglyceride levels under insulin-resistant conditions. Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance.
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