Myelin/oligodendrocyte glycoprotein–deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice
J. Clin. Invest. Cécile Delarasse, et al. 112:544 doi:10.1172/JCI15861 [Go to this article.]

Figure 6
MOG-specific T cells from MOG^–/– and MOG^+/+ mice are equally encephalitogenic. (a) EAE induced by the adoptive transfer of activated MOG-specific T cells from either MOG^–/– (n = 6) or MOG^+/+ (n = 7) mice into WT C57BL/6 mice. (b) EAE induced by the adoptive transfer of purified T cells from either MOG^–/– (n = 6) or MOG^+/+ (n = 5) mice into syngeneic αβ T cell–deficient recipients followed, 48 hours later, by rMOG immunization. For each protocol, data from two experiments are pooled and represent mean clinical score ± SEM plotted against time.