Myelin/oligodendrocyte glycoprotein–deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice
J. Clin. Invest. Cécile Delarasse, et al. 112:544 doi:10.1172/JCI15861 [Go to this article.]

Figure 2
Histological analyses of brains from MOG^+/+, nlacZ-MOG^+/–, and nlacZ-MOG^–/– animals. (a) Histochemical detection of β-gal activity on brain sections using X-gal as substrate. Left panel: No reaction product is observed in the brain of a MOG^+/+ mouse. Middle panel: X-gal staining of an nlacZ-MOG^+/– mouse. Blue reaction product is located in brain areas where mog is known to be transcribed. Right panel: Enlargement of a region (indicated by the rectangle) of the corpus callosum of the nlacZ-MOG^+/– mouse. (b) Immunohistofluorescent detection of MOG and β-gal in brain stem of MOG^+/+, nlacZ-MOG^+/–, or nlacZ-MOG^–/– mice with MOG-specific (green) and β-gal–specific (red) antibodies. (c) Electron micrographs of striatum sections of MOG^+/+ and MOG^–/– mice. The myelin sheaths in both types of mice show normal compaction, characterized by major dense and intraperiodic lines. Top, ×28,100; bottom, ×260,600.