JAK-STAT signaling in asthma
J. Clin. Invest. Alessandra B. Pernis, et al. 109:1279 doi:10.1172/JCI15786 [Go to this article.]

Figure 2
IgE in the pathogenesis of asthmatic responses. Production of Th2-type cytokines (IL-4 and IL-13) by T cells in response to antigens like airborne allergens will drive IgE synthesis by B cells. IgE can then bind to high-affinity IgE receptors on mast cells. Cross-linking of the bound IgE molecules upon reexposure to the antigen provokes mast cell degranulation with the subsequent release of a variety of mediators, which trigger both early and late inflammatory asthmatic responses.