Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways
J. Clin. Invest. Fabio Candotti, et al. 109:1261 doi:10.1172/JCI15769 [Go to this article.]

Figure 2
The development of lymphoid cells is dependent upon the expression and signaling by cytokine receptors, antigen receptors, and adhesion/accessory molecules. Mutations of many different genes can interfere with proper lymphoid development and function and, consequently, can lead to immunodeficiency.