Increased hair follicle proliferation following gonadectomy does not contribute to the wound healing response. (a) Day 3 macroscopic and histological wounds from intact wild-type and intact null (hr/hr) mice showed no differences in healing. By contrast, castrated hr/hr and castrated wild-type mice healed significantly more quickly. Magnification: ×10. (b) Quantification of wound areas at day 3 illustrated a significant decrease in area (accelerated healing) in the castrated hr/hr null (KO) animals compared with the intact hr/hr littermates, and wild-type (WT) castrated compared with wild-type intact. n = 6 per group; *P < 0.05.