Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
J. Clin. Invest. Xinping Zhang, et al. 109:1405 doi:10.1172/JCI15681 [Go to this article.]

Figure 6
Inflammation-induced intramembranous bone formation is reduced in COX-2^–/– mice. Titanium particles were surgically implanted onto the calvaria of wild-type (a), COX-1^–/– (b), and COX-2^–/– (c) mice as described in Methods, and representative H&E-stained sections are shown. Ectopic bone formation was measured, and the percentage of new bone width (brackets) is presented as the mean ± SEM (d). Statistical significance compared with wild-type is indicated (**P < 0.01).