Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis
J. Clin. Invest. Masha Fridkis-Hareli, et al. 109:1635 doi:10.1172/JCI15402 [
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Figure 3Suppression of EAE induced with the PLP 139-151 epitope by different random copolymers. SJL/J mice were co-injected subcutaneously with 50 μg of PLP 139-151 peptide and 500 μg of the random copolymers FAK, YFAK (0.2:0.8), YFAK (0.5:0.5), YFAK (0.8:0.2), or Cop 1, or with PLP 139-151 alone. The progression of the disease was monitored for the appearance of clinical symptoms on a daily basis. Results represent the mean daily score. Five to nine mice per group were used in each of two independent identical experiments that were combined.
