Min Li-Weber, Markus A. Weigand, Marco Giaisi, Dorothee Süss, Monika K. Treiber, Sven Baumann, Elena Ritsou, Raoul Breitkreutz, Peter H. Krammer
J Clin Invest.
2002;
110(5):681–690
doi:10.1172/JCI15073
This article Copyright © 2002, The American Society for Clinical Investigation
Abstract
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poptosis is a morphologically distinct form of cell death involved in many physiological and pathological processes. Expression of the CD95 (APO-1/Fas) ligand (CD95L) is critically involved in activation-induced cell death (AICD) of activated T cells. Here we show that the natural free radical scavenger vitamin E suppresses the activity of the transcription factors NF-κB and AP-1, thus blocking expression of CD95L and preventing T cell AICD. Since AICD is a major cause of T cell depletion in AIDS, we examined 35 HIV-1–positive individuals and found that their T cells are more susceptible to AICD than are T cells isolated from healthy controls. Administration of vitamin E suppresses CD95L mRNA expression and protects T cells of HIV-1–infected individuals from CD95-mediated apoptosis. This evidence that vitamin E can affect T cell survival may merit further clinical investigation.
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