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ITAMs versus ITIMs: striking a balance during cell regulation
Daniel D. Billadeau, Paul J. Leibson
Published in Volume 109, Issue 2
J Clin Invest. 2002; 109(2):161–168 doi:10.1172/JCI14843
This article Copyright © 2002, The American Society for Clinical Investigation
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Figure 2

A model of ITIM-related cellular regulation. Co-ligation of ITAM-containing activating receptors with ITIM-bearing inhibitory receptors facilitates the Src family PTK-dependent tyrosine phosphorylation of the ITIMs. For FcγRIIB, this creates high-affinity epitopes for SH2-containing SHIP and the subsequent hydrolysis of the membrane inositol phosphate PIP3. For killer cell Ig-like receptors (KIRs), the tyrosine-phosphorylated ITIMs recruit SH2-containing SHP-1 (and SHP-2), leading to a block in early PTK activation.

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