Hypothalamic Y2 receptors regulate bone formation
J. Clin. Invest. Paul A. Baldock, et al. 109:915 doi:10.1172/JCI14588 [Go to this article.]

Figure 8
Effect of hypothalamus-specific Y2 receptor deletion on trabecular bone cell activity in the distal femoral metaphysis. Osteoclast surface (a), osteoclast number (b), osteoblast surface (c), osteoblast number (d), osteoid surface (e), mineralizing surface (f), mineral apposition rate (g), and bone formation rate (h) of femurs from male Y2^+/+ Cre-adenovirus–injected or Y2^lox/lox GFP- adenovirus–injected control mice (white bars) compared with Y2^lox/lox Cre-adenovirus–injected knockouts (KO, black bars) at 15–17 weeks of age. Values are mean ± SD of five to seven mice per group. *P < 0.05 versus controls.