Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
J. Clin. Invest. Seiichi Oyadomari, et al. 109:525 doi:10.1172/JCI14550 [Go to this article.]

Figure 2
Northern blot analysis for insulin, Chop, and Bip mRNAs in the pancreas of male Akita mice. (a) Chemiluminescent images for insulin, Chop, and Bip mRNAs at the indicated ages are shown. Total RNAs (2.0 mg) from the pancreas of each genotype were subjected to Northern blot analysis. The results at 3, 6, and 9 weeks of age were obtained under essentially identical conditions. (b) Quantification of the results obtained in a, shown as mean ± SD (n = 3).