Partial deficiency of Thyroid transcription factor 1 produces predominantly neurological defects in humans and mice
J. Clin. Invest. Joachim Pohlenz, et al. 109:469 doi:10.1172/JCI14192 [Go to this article.]

Figure 3
Effect of Ttf1 gene deletion in one allele (Ttf1^+/–) on neurological and thyroid function of mice. Results are expressed as mean ± SEM. (a) Coordination was tested by the Rotarod test. Ttf1^+/– mice had significantly lower scores and, thus, worse coordination than wild-type littermates (+/+). (b) Ttf1^+/– mice had significantly higher serum TSH values than did Ttf1^+/+ mice, but (c) the T₄ concentration was not significantly different.