Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
J. Clin. Invest. Sophie Lanone, et al. 110:463 doi:10.1172/JCI14136 [Go to this article.]

Figure 5
Survival and terminal pathology of CC10-IL-13 mice and littermate control mice with wild-type and null MMP loci. (a) The effects of MMP-9 deficiency on survival. (b) The effects of MMP-12 deficiency on survival. In a and b comparisons are made of the survival of transgene^– mice with wild-type (squares) and null (triangles) MMP loci and transgene⁺ mice with wild-type (diamonds) and null (circles) MMP loci. Each point represents the survival of a minimum of six animals. (c) The airway and parenchymal abnormalities in lungs from near-terminal 4-month-old IL-13⁺/MMP-12^+/+ mice and 6.5-month-old IL-13⁺/MMP-12^–/– mice.